Studies of nucleophile ring opening of oxabicyclic systems in highly polar media: application to a total synthesis of antitumor agent, (-)-epothilone
Polyketides constitute an important family of natural products, having a broad spectrum of biological activity such as antitumor, antibiotic, antifungal, or immunomodulatory action.¹ Many of these compounds possess polypropionates (units with alternating hydroxyl and methyl group...
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| Language: | en |
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2006
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| Online Access: | http://etd.lib.montana.edu/etd/2006/diep/DiepN0806.pdf |