Effect of volume fraction of solids on the compressive stress-strain behavior of collagen-glycosaminoglycan scaffolds

Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2006. === Includes bibliographical references (leaf 35). === This thesis aims to examine the effect of volume fraction of solids in collagen-glycosaminoglycan (GAG) scaffolds on the compressive-strain b...

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Main Author: Leung, Janet (Janet H.)
Other Authors: Lorna Gibson.
Format: Others
Language:English
Published: Massachusetts Institute of Technology 2006
Subjects:
Online Access:http://hdl.handle.net/1721.1/35062
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spelling ndltd-MIT-oai-dspace.mit.edu-1721.1-350622019-05-02T15:55:50Z Effect of volume fraction of solids on the compressive stress-strain behavior of collagen-glycosaminoglycan scaffolds Leung, Janet (Janet H.) Lorna Gibson. Massachusetts Institute of Technology. Dept. of Materials Science and Engineering. Massachusetts Institute of Technology. Dept. of Materials Science and Engineering. Materials Science and Engineering. Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2006. Includes bibliographical references (leaf 35). This thesis aims to examine the effect of volume fraction of solids in collagen-glycosaminoglycan (GAG) scaffolds on the compressive-strain behavior of the structure and compare these results to the open-cell foam model. Collagen-GAG (CG) scaffolds have been used for regenerating skin, conjunctiva, and peripheral nerves with varying levels of success. In these uses, the temporary scaffolds are often deployed with a non-degradable support structure such as a waterproof film or a silicone neural tube which are removed after healing is complete if it is outside the body (for skin regeneration) or are expected to remain permanently in the body (for nerve regeneration). Unfortunately, leaving non-degradable implants in the body could provoke immune responses. At the same time, to remove supports that have been implanted in the body after healing has been completed would result in more injury to the site and other medical complications. For a truly temporary implant, the scaffold must in its entirety be degradable. Thus, the bulk mechanical properties of the scaffold are important to study. Previous research has concentrated on the effects of cells on the scaffolds on a microlevel. However, the scaffold must also be able to bear mechanical stress from surrounding tissues to keep the wound open and provide mechanical support for the body, if, for example, collagen or bone is being regenerated. Here, the bulk mechanical properties of the scaffold are tested under uniaxial, unconfined compression. The Young's modulus and critical stress are calculated from the experimental data and compared to the values predicted by the open-celled foam model. There is very good agreement between the low density scaffolds, with variability in the results increasing with increasing density and with hydration of the specimens. Further research should focus on the (cont.) However, the scaffold must also be able to bear mechanical stress from surrounding tissues to keep the wound open and provide mechanical support for the body, if, for example, collagen or bone is being regenerated. Here, the bulk mechanical properties of the scaffold are tested under uniaxial, unconfined compression. The Young's modulus and critical stress are calculated from the experimental data and compared to the values predicted by the open-celled foam model. There is very good agreement between the low density scaffolds, with variability in the results increasing with increasing density and with hydration of the specimens. Further research should focus on the origins and the effects of heterogeneities observed in the scaffold structures on the mechanical behavior. by Janet Leung. S.B. 2006-12-18T20:01:04Z 2006-12-18T20:01:04Z 2006 2006 Thesis http://hdl.handle.net/1721.1/35062 71227604 eng M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. http://dspace.mit.edu/handle/1721.1/7582 39 leaves 1743551 bytes 1743152 bytes application/pdf application/pdf application/pdf Massachusetts Institute of Technology
collection NDLTD
language English
format Others
sources NDLTD
topic Materials Science and Engineering.
spellingShingle Materials Science and Engineering.
Leung, Janet (Janet H.)
Effect of volume fraction of solids on the compressive stress-strain behavior of collagen-glycosaminoglycan scaffolds
description Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2006. === Includes bibliographical references (leaf 35). === This thesis aims to examine the effect of volume fraction of solids in collagen-glycosaminoglycan (GAG) scaffolds on the compressive-strain behavior of the structure and compare these results to the open-cell foam model. Collagen-GAG (CG) scaffolds have been used for regenerating skin, conjunctiva, and peripheral nerves with varying levels of success. In these uses, the temporary scaffolds are often deployed with a non-degradable support structure such as a waterproof film or a silicone neural tube which are removed after healing is complete if it is outside the body (for skin regeneration) or are expected to remain permanently in the body (for nerve regeneration). Unfortunately, leaving non-degradable implants in the body could provoke immune responses. At the same time, to remove supports that have been implanted in the body after healing has been completed would result in more injury to the site and other medical complications. For a truly temporary implant, the scaffold must in its entirety be degradable. Thus, the bulk mechanical properties of the scaffold are important to study. Previous research has concentrated on the effects of cells on the scaffolds on a microlevel. However, the scaffold must also be able to bear mechanical stress from surrounding tissues to keep the wound open and provide mechanical support for the body, if, for example, collagen or bone is being regenerated. Here, the bulk mechanical properties of the scaffold are tested under uniaxial, unconfined compression. The Young's modulus and critical stress are calculated from the experimental data and compared to the values predicted by the open-celled foam model. There is very good agreement between the low density scaffolds, with variability in the results increasing with increasing density and with hydration of the specimens. Further research should focus on the === (cont.) However, the scaffold must also be able to bear mechanical stress from surrounding tissues to keep the wound open and provide mechanical support for the body, if, for example, collagen or bone is being regenerated. Here, the bulk mechanical properties of the scaffold are tested under uniaxial, unconfined compression. The Young's modulus and critical stress are calculated from the experimental data and compared to the values predicted by the open-celled foam model. There is very good agreement between the low density scaffolds, with variability in the results increasing with increasing density and with hydration of the specimens. Further research should focus on the origins and the effects of heterogeneities observed in the scaffold structures on the mechanical behavior. === by Janet Leung. === S.B.
author2 Lorna Gibson.
author_facet Lorna Gibson.
Leung, Janet (Janet H.)
author Leung, Janet (Janet H.)
author_sort Leung, Janet (Janet H.)
title Effect of volume fraction of solids on the compressive stress-strain behavior of collagen-glycosaminoglycan scaffolds
title_short Effect of volume fraction of solids on the compressive stress-strain behavior of collagen-glycosaminoglycan scaffolds
title_full Effect of volume fraction of solids on the compressive stress-strain behavior of collagen-glycosaminoglycan scaffolds
title_fullStr Effect of volume fraction of solids on the compressive stress-strain behavior of collagen-glycosaminoglycan scaffolds
title_full_unstemmed Effect of volume fraction of solids on the compressive stress-strain behavior of collagen-glycosaminoglycan scaffolds
title_sort effect of volume fraction of solids on the compressive stress-strain behavior of collagen-glycosaminoglycan scaffolds
publisher Massachusetts Institute of Technology
publishDate 2006
url http://hdl.handle.net/1721.1/35062
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