Exploring alternans characteristics of electrocardiogram for prediction of Paroxysmal Atrial Fibrillation

• Main Author: Dosani, Adnan, 1982-
• Other Authors: Richard Cohen.
• Format: Others
• Language: en_US
• Published: Massachusetts Institute of Technology 2005
• Subjects: Electrical Engineering and Computer Science.
• Online Access: http://hdl.handle.net/1721.1/28726

Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2004. === Includes bibliographical references (leaves 93-96). === The goal of our thesis was to investigate if P-wave and PQ segment alternans can be used to detect and predict Paroxysmal Atrial Fibrillation (PAF) from an Electrocardiogram (ECG). The work involved implementing an algorithm for computing alternans information for a region of ECG, applying the algorithm to derive P-wave and PQ segment alternans information, and analyzing data generated for normal and PAF ECGs for evidence of any distinguishable predictive characteristics. Based on analysis of total 80 patient records (35 normal and 45 PAF) with validation on 30 records randomly selected from those (achieving c-indexes between 0.66 and 0.70), we concluded that alternans can potentially be a useful predictor for PAF. === by Adnan Dosani. === S.M.