Computational studies on the factors influencing stabilities of collagen-like peptides
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2004. === Includes bibliographical references (leaf 26). === In this study, thermodynamic integration and molecular dynamics methods were used to elucidate the factors affecting stabilities of collagen-like peptides. We propos...
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| Format: | Others |
| Language: | en_US |
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Massachusetts Institute of Technology
2005
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| Online Access: | http://hdl.handle.net/1721.1/28707 |
| Summary: | Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2004. === Includes bibliographical references (leaf 26). === In this study, thermodynamic integration and molecular dynamics methods were used to elucidate the factors affecting stabilities of collagen-like peptides. We proposed to investigate three specific aspects: (1) the stabilizing effect of hydroxyproline (Hyp), (2) the destabilizing effect of replacing Gly, and (3) the role of water mediated hydrogen bonds. A better understanding of the origins of the stabilities of collagens will help in the design of new biomaterials and the treatment of collagen-related diseases. === by Nai-yuan Chang. === S.M. |
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