Re-strengthening demineralized bone via tannin-iron crosslinking

• Main Author: Hart, Sawyer(Sawyer H.)
• Other Authors: Niels Holten-Andersen.
• Format: Others
• Language: English
• Published: Massachusetts Institute of Technology 2020
• Subjects: Materials Science and Engineering.
• Online Access: https://hdl.handle.net/1721.1/124588

Thesis: S.B., Massachusetts Institute of Technology, Department of Materials Science and Engineering, 2019 === Cataloged from PDF version of thesis. === Includes bibliographical references (pages [30]-[31]). === As the world population continues to age, the social and economic impacts resulting from osteoporosis will continue to rise. New treatments for the disease are needed now more than ever. Using tannin iron complexes we show that thin film deposition of the complexes are not only possible but effective at strengthening demineralized bone. Furthermore we show that by taking advantage of newly discovered tris-complexes that are able to form between tannic acid and ferrous iron ion in solution, the strengthening ability of the film increases dramatically. Specifically, we show that tannin iron tris-complex coating results in a 1062% increase in the flexural modulus for fully hydrated and demineralized bone. === by Sawyer Hart. === S.B. === S.B. Massachusetts Institute of Technology, Department of Materials Science and Engineering