Design of selective peptide inhibitors of anti-apoptotic Bfl-1 using experimental screening, structure-based design, and data-driven modeling
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, 2018. === Cataloged from PDF version of thesis. === Includes bibliographical references. === Protein-protein interactions are central to all biological processes. Designer reagents that selectively bind to proteins and inh...
Main Author: | Jenson, Justin Michael |
---|---|
Other Authors: | Amy E. Keating. |
Format: | Others |
Language: | English |
Published: |
Massachusetts Institute of Technology
2019
|
Subjects: | |
Online Access: | http://hdl.handle.net/1721.1/120631 |
Similar Items
-
Tertiary Structural Motif Sequence Statistics Enable Facile Prediction and Design of Peptides that Bind Anti-apoptotic Bfl-1 and Mcl-1
by: Frappier, Vincent, et al.
Published: (2021) -
Epistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1
by: Justin M Jenson, et al.
Published: (2017-06-01) -
Epistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1
by: Ryan, Jeremy A., et al.
Published: (2018) -
Tertiary Structural Motif Sequence Statistics Enable Facile Prediction and Design of Peptides that Bind Anti-apoptotic Bfl-1 and Mcl-1
Published: (2020) -
Anti-apoptotic BFL-1 is the major effector in activation-induced human mast cell survival.
by: Maria Ekoff, et al.
Published: (2012-01-01)