Mcl-1 in breast cancer: regulation by the EGF receptor family and role in cell survival and drug resistance
Myeloid Cell Leukemia-1 (Mcl-1) is a widely expressed anti-apoptotic member of the Bcl-2 family that is elevated in a variety of tumour types including breast cancer. Mcl-1 promotes tumour cell survival and drug resistance and was a mechanism of resistance to first generation Bcl-2 family inhibitors...
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| Language: | en_US |
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2011
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| Online Access: | http://hdl.handle.net/1993/4334 |