The Adaptation of Chinese Hamster Ovary Cells to Hypothermic Temperatures Increases Yields of Monomeric Recombinant Interferon-beta
Mild hypothermic conditions (30ºC to 33ºC) have previously been shown to increase cell specific productivity (Qp) of recombinant proteins from mammalian cells. However, this is often associated with a lower growth rate which off-sets any potential advantage of higher product titres. This thesis desc...
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| Language: | en_US |
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2009
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| Online Access: | http://hdl.handle.net/1993/3192 |