Linking the tropism and transduction efficiency of porcine-derived adeno-associated viruses to their transgene-mediated protective efficacy
Adeno-associated virus (AAV) is a small, non-pathogenic virus, exploited as a vector for gene therapy applications, with many successful clinical trials. However, these vectors are based on human and non-human primate AAVs, to which there exists pre-existing immunity in the general population. We...
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2014
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| Online Access: | http://hdl.handle.net/1993/23945 |