Line Drive: L1 Element Orthologous Loci

The L1Hs preTa subfamily is one of the youngest L1 families. It originated after the divergence of human and chimpanzee about 2.34 mya, and therefore is only found in the human genome. Some elements were inserted so recently that they are not fixed in the population. Thirty three of the 254 L1Hs pre...

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Main Author: Ho, Huei Jin
Other Authors: Mohamed Noor
Format: Others
Language:en
Published: LSU 2004
Subjects:
Online Access:http://etd.lsu.edu/docs/available/etd-08112004-104811/
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spelling ndltd-LSU-oai-etd.lsu.edu-etd-08112004-1048112013-01-07T22:49:24Z Line Drive: L1 Element Orthologous Loci Ho, Huei Jin Biochemistry (Biological Sciences) The L1Hs preTa subfamily is one of the youngest L1 families. It originated after the divergence of human and chimpanzee about 2.34 mya, and therefore is only found in the human genome. Some elements were inserted so recently that they are not fixed in the population. Thirty three of the 254 L1Hs preTa elements are polymorphic for the absence/presence of the insertion, making them useful markers for studying phylogenetics and human population genetics. However, the problem of homoplasy can diminish the value of using L1 elements as phylogenetic and population genetic markers. Examination of the L1Hs preTa orthologous insertion sites in a range of non-human primates revealed an assortment of events that altered the size of the pre-integration or empty sites. Only two cases of parallel mobile element insertions into the same pre-integration sites were discovered, one involves an AluY in green monkey and the other a L1PA8 element in owl monkey. However, both elements were clearly distinguishable from their human counterparts. No preTa L1 element gene conversion events were observed in any of the loci analyzed. Therefore, we conclude that L1 elements are homoplasy-free genetic characters. Mohamed Noor Mark Batzer David Donze LSU 2004-08-11 text application/pdf http://etd.lsu.edu/docs/available/etd-08112004-104811/ http://etd.lsu.edu/docs/available/etd-08112004-104811/ en unrestricted I hereby certify that, if appropriate, I have obtained and attached herein a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to LSU or its agents the non-exclusive license to archive and make accessible, under the conditions specified below and in appropriate University policies, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report.
collection NDLTD
language en
format Others
sources NDLTD
topic Biochemistry (Biological Sciences)
spellingShingle Biochemistry (Biological Sciences)
Ho, Huei Jin
Line Drive: L1 Element Orthologous Loci
description The L1Hs preTa subfamily is one of the youngest L1 families. It originated after the divergence of human and chimpanzee about 2.34 mya, and therefore is only found in the human genome. Some elements were inserted so recently that they are not fixed in the population. Thirty three of the 254 L1Hs preTa elements are polymorphic for the absence/presence of the insertion, making them useful markers for studying phylogenetics and human population genetics. However, the problem of homoplasy can diminish the value of using L1 elements as phylogenetic and population genetic markers. Examination of the L1Hs preTa orthologous insertion sites in a range of non-human primates revealed an assortment of events that altered the size of the pre-integration or empty sites. Only two cases of parallel mobile element insertions into the same pre-integration sites were discovered, one involves an AluY in green monkey and the other a L1PA8 element in owl monkey. However, both elements were clearly distinguishable from their human counterparts. No preTa L1 element gene conversion events were observed in any of the loci analyzed. Therefore, we conclude that L1 elements are homoplasy-free genetic characters.
author2 Mohamed Noor
author_facet Mohamed Noor
Ho, Huei Jin
author Ho, Huei Jin
author_sort Ho, Huei Jin
title Line Drive: L1 Element Orthologous Loci
title_short Line Drive: L1 Element Orthologous Loci
title_full Line Drive: L1 Element Orthologous Loci
title_fullStr Line Drive: L1 Element Orthologous Loci
title_full_unstemmed Line Drive: L1 Element Orthologous Loci
title_sort line drive: l1 element orthologous loci
publisher LSU
publishDate 2004
url http://etd.lsu.edu/docs/available/etd-08112004-104811/
work_keys_str_mv AT hohueijin linedrivel1elementorthologousloci
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