Syntheses of Trimethylamine- and Phosphonate-Substituted Carboranylporphyrins for Application in Boron Neutron Cancer Therapy

Chapter 1 contains an introduction to porphyrins and carboranylporphyrins, including their physical properties, history, methods of synthesis, medicinal applications, and an overview of recently published compounds. Chapter 2 contains the total synthesis of a series of trimethylamine- and phosphonat...

Full description

Bibliographic Details
Main Author:	Easson, Michael William
Other Authors:	M. Graca H. Vicente
Format:	Others
Language:	en
Published:	LSU 2008
Subjects:	Chemistry
Online Access:	http://etd.lsu.edu/docs/available/etd-04092008-140338/

id	ndltd-LSU-oai-etd.lsu.edu-etd-04092008-140338
record_format	oai_dc
spelling	ndltd-LSU-oai-etd.lsu.edu-etd-04092008-1403382013-01-07T22:51:40Z Syntheses of Trimethylamine- and Phosphonate-Substituted Carboranylporphyrins for Application in Boron Neutron Cancer Therapy Easson, Michael William Chemistry Chapter 1 contains an introduction to porphyrins and carboranylporphyrins, including their physical properties, history, methods of synthesis, medicinal applications, and an overview of recently published compounds. Chapter 2 contains the total synthesis of a series of trimethylamine- and phosphonate-substituted carboranylporphyrins for application in boron neutron capture therapy (BNCT), including characterization by proton nuclear magnetic resonance spectroscopy, matrix-assisted time-of-flight mass spectroscopy, high resolution mass spectroscopy, UV-Vis spectrophotometry, X-ray crystallography, and melting point apparatus. Chapter 3 contains synthetic methods which were investigated as alternate routes to porphyrin synthesis and functionalization. Chapter 4 presents the in vitro biological evaluation of trimethylamine- and phosphonate-substituted carboranylporphyrins. M. Graca H. Vicente Fareed Aboul-ela William Daly Andrew Maverick Kevin M. Smith LSU 2008-04-09 text application/pdf http://etd.lsu.edu/docs/available/etd-04092008-140338/ http://etd.lsu.edu/docs/available/etd-04092008-140338/ en unrestricted I hereby certify that, if appropriate, I have obtained and attached herein a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to LSU or its agents the non-exclusive license to archive and make accessible, under the conditions specified below and in appropriate University policies, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report.
collection	NDLTD
language	en
format	Others
sources	NDLTD
topic	Chemistry
spellingShingle	Chemistry Easson, Michael William Syntheses of Trimethylamine- and Phosphonate-Substituted Carboranylporphyrins for Application in Boron Neutron Cancer Therapy
description	Chapter 1 contains an introduction to porphyrins and carboranylporphyrins, including their physical properties, history, methods of synthesis, medicinal applications, and an overview of recently published compounds. Chapter 2 contains the total synthesis of a series of trimethylamine- and phosphonate-substituted carboranylporphyrins for application in boron neutron capture therapy (BNCT), including characterization by proton nuclear magnetic resonance spectroscopy, matrix-assisted time-of-flight mass spectroscopy, high resolution mass spectroscopy, UV-Vis spectrophotometry, X-ray crystallography, and melting point apparatus. Chapter 3 contains synthetic methods which were investigated as alternate routes to porphyrin synthesis and functionalization. Chapter 4 presents the in vitro biological evaluation of trimethylamine- and phosphonate-substituted carboranylporphyrins.
author2	M. Graca H. Vicente
author_facet	M. Graca H. Vicente Easson, Michael William
author	Easson, Michael William
author_sort	Easson, Michael William
title	Syntheses of Trimethylamine- and Phosphonate-Substituted Carboranylporphyrins for Application in Boron Neutron Cancer Therapy
title_short	Syntheses of Trimethylamine- and Phosphonate-Substituted Carboranylporphyrins for Application in Boron Neutron Cancer Therapy
title_full	Syntheses of Trimethylamine- and Phosphonate-Substituted Carboranylporphyrins for Application in Boron Neutron Cancer Therapy
title_fullStr	Syntheses of Trimethylamine- and Phosphonate-Substituted Carboranylporphyrins for Application in Boron Neutron Cancer Therapy
title_full_unstemmed	Syntheses of Trimethylamine- and Phosphonate-Substituted Carboranylporphyrins for Application in Boron Neutron Cancer Therapy
title_sort	syntheses of trimethylamine- and phosphonate-substituted carboranylporphyrins for application in boron neutron cancer therapy
publisher	LSU
publishDate	2008
url	http://etd.lsu.edu/docs/available/etd-04092008-140338/
work_keys_str_mv	AT eassonmichaelwilliam synthesesoftrimethylamineandphosphonatesubstitutedcarboranylporphyrinsforapplicationinboronneutroncancertherapy
_version_	1716477244191277056

Syntheses of Trimethylamine- and Phosphonate-Substituted Carboranylporphyrins for Application in Boron Neutron Cancer Therapy

Similar Items