Tobacco smoking in South African patients with suspected tuberculosis

Primary objectives: To estimate the prevalence of tobacco smoking in patients with suspected tuberculosis in South Africa and to validate the accuracy of self reported smoking with plasma cotinine. Secondary objective: To explore the association between tobacco smoking and the spectrum of tuberculo...

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Bibliographic Details
Main Author: Brunet, Laurence
Other Authors: Madhukar Pai (Supervisor)
Format: Others
Language:en
Published: McGill University 2010
Subjects:
Online Access:http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=95112
Description
Summary:Primary objectives: To estimate the prevalence of tobacco smoking in patients with suspected tuberculosis in South Africa and to validate the accuracy of self reported smoking with plasma cotinine. Secondary objective: To explore the association between tobacco smoking and the spectrum of tuberculosis disease and infection. Methods: This project consists of a cross-sectional analysis of a prospective cohort study of patients with suspected tuberculosis from three tuberculosis clinics in Cape Town, South Africa. Results: Of the 424 patients included in the study, 56.6% were current smokers and 15.6% were ex-smokers. Moreover, 28.8% of ex-smokers quit less than a year before seeking care at the tuberculosis clinic. The sensitivity and specificity of self-reported smoking were 89.0% and 81.1% respectively, using plasma cotinine as a reference standard. Conclusion: The prevalence of smoking among patients with suspected tuberculosis is high in Cape Town, South Africa and self-report is an acceptable measure of smoking in that population. === Objectifs principaux : Estimer la prévalence du tabagisme chez des patients investigués pour la tuberculose au Cap, Afrique du Sud et vérifier la validité de l'auto déclaration par la mesure de la cotinine sérique. Objectif secondaire : Explorer l'association entre le tabagisme et la tuberculose, de l'infection à la maladie. Méthodes : Il s'agit d'une analyse transversale d'une étude de cohorte dans trois cliniques du Cap, Afrique du Sud. Résultats : Parmi les 424 patients, 56.6% étaient fumeurs et 15.6% étaient d'ex fumeurs. De plus, 28.8% des ex fumeurs ont arrêté moins d'un an avant d'être recrutés. La sensibilité et la spécificité de l'auto déclaration étaient respectivement de 89.0% et 81.1% en utilisant la cotinine sérique comme référence. Conclusion : La prévalence du tabagisme chez les patients investigués pour la tuberculose est élevée au Cap, Afrique du Sud et l'utilisation de l'auto déclaration est acceptable dans cette population.