Modified nucleotides and nucleic acids for the discovery of antiretroviral agents targeting HIV-1 reverse transcriptase
The reverse transcriptase (RT) of the human immunodeficiency virus (HIV) has both polymerase and ribonuclease H (RNase H) activity, and is a key enzyme in the HIV life cycle as it converts the viral RNA genome into double-stranded DNA. A series of studies built around the theme of chemically modifie...
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| Format: | Others |
| Language: | en |
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McGill University
2010
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| Online Access: | http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=94986 |