The total synthesis of (-)-ent-Anhydromyriocin 1,2 : a thesis
The optical antipode of anhydromyriocin, the (gamma)-lactone derived from the antibiotic myriocin, was synthesized from L-arabinose. The identity of myriocin and thermozymocidin was confirmed, and their relative and absolute stereochemistries were established. In contrast to its natural enantiomer,...
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| Format: | Others |
| Language: | en |
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McGill University
1980
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| Online Access: | http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=68579 |
| Summary: | The optical antipode of anhydromyriocin, the (gamma)-lactone derived from the antibiotic myriocin, was synthesized from L-arabinose. The identity of myriocin and thermozymocidin was confirmed, and their relative and absolute stereochemistries were established. In contrast to its natural enantiomer, (-)-ent-anhydromyriocin showed but little antifungal activity. |
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