The synthesis of methyl trihydroxyeicosatrienoates and related compounds /
Efficient syntheses for appropriately derivatized methyl 8R,9(R and S), 11R-trihydroxy-12-oxododeca-5Z-enoates (53, 59) via their respective 5,6-anhydro-3-deoxy-1,2-0-isopropylidene-(alpha)-D-hexofuranoses (18 and 38) are described. These aldehydes were subsequently converted to the corresponding me...
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| Format: | Others |
| Language: | en |
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McGill University
1981
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| Online Access: | http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=68571 |
| Summary: | Efficient syntheses for appropriately derivatized methyl 8R,9(R and S), 11R-trihydroxy-12-oxododeca-5Z-enoates (53, 59) via their respective 5,6-anhydro-3-deoxy-1,2-0-isopropylidene-(alpha)-D-hexofuranoses (18 and 38) are described. These aldehydes were subsequently converted to the corresponding methyl 8(R and S), 9(R and S), 11R-trihydroxy-eicosa-5Z,12E,14Z-trienoates (64, 72, 82, 91). Model studies towards the synthesis of 8R,11R,15(R and S)-trihydroxy-9S,12-oxyeicosa-5Z,13E-dienoic acids (1) were carried out. |
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