Investigation and treatment of ABeta- and TGF-Beta1- related cerebrovascular dysfunction in Alzheimer's Disease

Investigation and treatment of ABeta- and TGF-Beta1- related cerebrovascular dysfunction in Alzheimer's Disease

ABSTRACT Alzheimer's disease (AD) is characterized by neurodegeneration, memory loss and premature cerebral circulatory deficits marked by a vascular structural pathology thought to involve elevated levels of amyloid-beta (Aβ) and transforming growth factor-beta 1 (TGF-β1). We sought to i...

Full description

Bibliographic Details
Main Author:	Nicolakakis, Nektaria
Other Authors:	Edith Hamel (Supervisor)
Format:	Others
Language:	en
Published:	McGill University 2009
Subjects:	Health Sciences - Mental Health
Online Access:	http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=66738

Similar Items

The nuclear receptor PPARγ as a therapeutic target for cerebrovascular and brain dysfunction in Alzheimer's disease
by: Nektaria Nicolakakis, et al.
Published: (2010-05-01)

Highly specific and ultrasensitive plasma test detects Abeta(1–42) and Abeta(1–40) in Alzheimer’s disease
by: Elisabeth H. Thijssen, et al.
Published: (2021-05-01)

Mitochondrial mislocalization underlies Abeta42-induced neuronal dysfunction in a Drosophila model of Alzheimer's disease.
by: Kanae Iijima-Ando, et al.
Published: (2009-12-01)

Consequence of Abeta immunization on the vasculature of human Alzheimer's disease brain
by: Boche, D., et al.
Published: (2008)

Effect of active Abeta immunotherapy on neurons in human Alzheimer's disease
by: Paquet, Claire, et al.
Published: (2015)

Effects of Monoclonal Anti-Abeta Antibodies on the Amyloid Beta Peptide Fibrillogenesis and their Involvement in the Clearance of Alzheimer's Disease Plaques
by: Jimenez, Jeffy Pilar
Published: (2010)

Bifunctional Modulators of Abeta Aggregation as Potential Agents for Alzheimer's Disease Therapy
by: Li-Hsin Hsu, et al.
Published: (2013)

APOE and Alzheimer’s Disease: Neuroimaging of Metabolic and Cerebrovascular Dysfunction
by: Jason A. Brandon, et al.
Published: (2018-06-01)

Simvastatin improves cerebrovascular function and counters soluble amyloid-beta, inflammation and oxidative stress in aged APP mice
by: Xin-Kang Tong, et al.
Published: (2009-09-01)

Neuropathology after active Abeta42 immunotherapy: implications for Alzheimer's disease pathogenesis.
by: Boche, Delphine, et al.
Published: (2010)

Unraveling Alzheimer's disease: insight into the influence of apolipoprotein E isoforms on Abeta aggregation
by: Cerf, Emilie
Published: (2011)

Role of neuropeptide Y in emotional dysfunctional conditions
by: Morales Medina, Julio
Published: (2012)

Angiotensin II type 1 receptor blocker losartan prevents and rescues cerebrovascular, neuropathological and cognitive deficits in an Alzheimer’s disease model
by: Brice Ongali, et al.
Published: (2014-08-01)

Cerebrovascular disease and câncer
by: Sofia de Castro Neves Padilha
Published: (2020)

How cholesterol constrains glycolipid conformation for optimal recognition of Alzheimer's beta amyloid peptide (Abeta1-40).
by: Nouara Yahi, et al.
Published: (2010-01-01)

Persistent amyloidosis following suppression of Abeta production in a transgenic model of Alzheimer disease.
by: Joanna L Jankowsky, et al.
Published: (2005-12-01)

Persistent amyloidosis following suppression of Abeta production in a transgenic model of Alzheimer disease.
Published: (2005-12-01)

Innovation rate, brain size and species richness in birds
by: Nicolakakis, Nektaria.
Published: (2001)

Involvement of TGF-beta in skin photoaging
by: Choi, Won Seon, 1975-
Published: (2008)

Physiological mouse brain Abeta levels are not related to the phosphorylation state of threonine-668 of Alzheimer's APP.
by: Yoshitake Sano, et al.
Published: (2006-12-01)

Inhibition of GSK-3 ameliorates Abeta pathology in an adult-onset Drosophila model of Alzheimer's disease.
by: Oyinkan Sofola, et al.
Published: (2010-09-01)

Saliva levels of Abeta1-42 as potential biomarker of Alzheimer's disease: a pilot study
by: Antequera Desiree, et al.
Published: (2010-11-01)

The Roles of TGF-β Signaling in Cerebrovascular Diseases
by: Yizhe Zhang, et al.
Published: (2020-09-01)

Evaluation of Mental Health and Related Factors Among Patients with Beta-Thalassemia Major in South East of Iran
by: Morteza Ashrafi, et al.
Published: (2012-04-01)

Evaluation of Mental Health and Related Factors among Patients with Beta-thalassemia Major in South East of Iran.
by: Majid Naderi, et al.
Published: (2012-03-01)

Association of cerebrovascular dysfunction with the development of Alzheimer’s disease-like pathology in OXYS rats
by: Natalia A. Stefanova, et al.
Published: (2018-02-01)

TGF-[beta] receptors on human chondrocytes : hetero-oligomerization and function
by: Parker, Wendy Lynne
Published: (2003)

Primary prevention of cerebrovascular diseases
by: Stančić Ana, et al.
Published: (2015-01-01)

Specific Binding of Alzheimer’s Abeta Peptide Fibrils to Single Walled Carbon Nanotubes
by: Steingrimur Stefansson, et al.
Published: (2012-10-01)

Effects of Diaphragmatic Breathing and Guided Imagery on Heart Rate Variability, Interleukin-1 Beta, and Mood in Adult Women with Thyroid Diseases
by: Trasko, Carolyn
Published: (2018)

Towards an early diagnosis of Alzheimer's disease: development of an ATR-FTIR biosensor for the detection of Abeta toxic conformations
by: Kleiren, Emilie
Published: (2013)

Half of the Sky| Integrating the Relational Right Brain in Adolescent Treatment
by: Mourad, Christine A.
Published: (2017)

Masculinity and mental health treatment initiation for former political prisoners in Yangon, Myanmar – a qualitative investigation
by: Daniel P. Lakin, et al.
Published: (2021-01-01)

Predictor Factors of Perceived Health in Family Caregivers of People Diagnosed with Mild or Moderate Alzheimer’s Disease
by: María Dolores Ruiz-Fernández, et al.
Published: (2019-10-01)

Is Abeta a sufficient Biomarker for monitoring anti-Abeta clinical studies? A critical review.
by: Jens eMoreth, et al.
Published: (2013-07-01)

Concordant association of insulin degrading enzyme gene (IDE) variants with IDE mRNA, Abeta, and Alzheimer's disease.
by: Minerva M Carrasquillo, et al.
Published: (2010-01-01)

Synaptic Alterations in Mouse Models for Alzheimer Disease—A Special Focus on N-Truncated Abeta 4-42
by: Katharina Dietrich, et al.
Published: (2018-03-01)

Concordant association of insulin degrading enzyme gene (IDE) variants with IDE mRNA, abeta, and alzheimer's disease.
by: Carrasquillo, Minerva M., et al.
Published: (2010)

Physical exercise as a preventive and therapeutic strategy against behavioral dysfunction in Alzheimer's disease.
by: Telma Sofia Correia Bernardo
Published: (2019)

The Beta Amyloid Dysfunction (BAD) Hypothesis for Alzheimer’s Disease
by: Heinz Hillen
Published: (2019-11-01)

Cannot write session to /tmp/vufind_sessions/sess_ejhaa7iprdianjd2v8eauvcue4