Oxidative stress and antioxidant intake in HIV-related wasting

• Main Author: Callow, Lisa Jane.
• Other Authors: Kubow, Stan (advisor)
• Format: Others
• Language: en
• Published: McGill University 2000
• Subjects: Oxidative Stress.; Active oxygen > Physiological effect.; HIV infections > Complications.; HIV infections > Nutritional aspects.; Antioxidants > Health aspects.
• Online Access: http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=33385

Weight loss is a common occurrence in patients with human immunodeficiency virus (HIV) and contributes to further debilitation in the acquired immune deficiency syndrome (AIDS). Wasting syndrome (WS) is defined as 10% or more unintentional weight loss from usual body weight. The etiology of WS includes alterations in metabolism, which contribute to loss of lean body mass. Cytokine driven oxidative stress may play a critical role in the metabolic pathways that lead to HIV wasting. Studies have shown that that patients infected with HIV may have a depleted antioxidant (AO) defense system, the integrity of which is needed to efficiently scavenge reactive oxygen species (ROS). It has been theorised that low AO intake may contribute to a depressed AO defense system, which drives oxidative stress (OS). In this study we examined 16 subjects who had documented WS but no active infectious process, stratified into 10 to 15% weight loss (n = 7) and over 15% weight loss (n = 9) groups, and reported on oxidative stress measures and AO intake. (Abstract shortened by UMI.)