The effect of glycemic control on protein metabolism in obese subjects with type II diabetes mellitus

• Main Author: Styhler, Karin
• Other Authors: Koski, K. G. (advisor)
• Format: Others
• Language: en
• Published: McGill University 1995
• Subjects: Non-insulin-dependent diabetes > Nutritional aspects.; Proteins > Metabolism.; Overweight persons.
• Online Access: http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=23942

We questioned whether improved glycemic control achieved by oral agent (gliclazide) would correct the altered protein metabolism during an iso-energetic (ISO) and a low energetic (50% of ISO) diets. Seven diabetic (DM) and 7 matched obese control (OB) subjects were give ISO for 14 (DM) or 7 (OB) days, followed by 28 days of the low energetic diet with constant 1.5 g protein/kg BMI$ sb{25}$/d. Giclazide (+ metformin in 4 DM) was given during days 8-14 of ISO and the low energety diet to DM. With ISO and gliclazide, fasting plasma glucose decreased and plasma insulin and nitrogen retention increased while 3-methylhistidine excretion and resting metablic rate decreased to levels no longer different from OB. With moderate energy restriction, weight decreased in all subjects and glycemia normalized in DM. Nitrogen equilibrium was maintained and 3-methylhistidine excretion did not change. The altered protein metabolism observed during hyperglycemia can be improved with oral hypoglycemic agent therapy $ pm$ the low energy diet. Moderate energy restriction with oral hypoglycemic agent therapy achieves diabetes control, nitrogen equilibrium, and a modest decrease in resting metabolic rate.