Molecular changes in the aging osteoblast

• Main Author: Duque, Gustavo
• Format: Others
• Language: en
• Published: McGill University 2003
• Subjects: Health Sciences - Medicine and Surgery
• Online Access: http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=19466

Aging is the consequence ofan array of phenotypic variations that appear to involve intrinsic or constitutional properties in all cells and systems, including qualitative and quantitative alterations in development, maturational structure and function. The aging process in bone involves a set ofchanges in bone cells differentiation, interaction and premature death. Osteoblasts are the cells most affected during the aging process in bone due to their complex mechanisms ofdifferentiation, their interaction with honnones and growth factors and their progression to apoptosis.