Protamine-heparin titration methods for the determination of circulating anti-coagulants

• Main Author: De Leeuw, Nannie K.
• Other Authors: Lowenstein, L. (Supervisor)
• Format: Others
• Language: en
• Published: McGill University 1950
• Subjects: Experimental Medicine.
• Online Access: http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=122693

The hemorrhagic syndromes that occurred after atomic bomb irradiation (1) have attracted attention, because the phenomena did not seem to be fully explicable on the basis of thrombocytopenia alone. It was first suggested by Allen and Jacobson (2), that an excess of heparin in the blood might be the cause of the decreased coagulability and bleeding tendency after acute ionizing irradiation. Allen then developed a heparin-protamine titration test (3) tor the demonstration of heparin or heparin-like substances in the circulating blood.