A histological and histochemical study of the development of the sternum in thalidomide-treated rats.

A histological and histochemical study of the development of the sternum in thalidomide-treated rats.

It is now well established that certain chemical compounds, administered to animals in early pregnancy, can adversely influence the development of the fetus, resulting in congenital malformations. Recently, it bas been shown that thalidomide, a sedative drug, may induce skeletal defects in the offsp...

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Bibliographic Details
Main Author: Globus, Morton.
Other Authors: Gibson, M. (Supervisor)
Format: Others
Language:en
Published: McGill University 1965
Subjects:
Zoology.
Sternum.
Rodents > Embryology.
Rats.
Thalidomide.
Online Access:http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=117795
id ndltd-LACETR-oai-collectionscanada.gc.ca-QMM.117795
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spelling ndltd-LACETR-oai-collectionscanada.gc.ca-QMM.1177952014-02-13T04:11:02ZA histological and histochemical study of the development of the sternum in thalidomide-treated rats.Globus, Morton.Zoology.Sternum.Rodents -- Embryology.Rats.Thalidomide.It is now well established that certain chemical compounds, administered to animals in early pregnancy, can adversely influence the development of the fetus, resulting in congenital malformations. Recently, it bas been shown that thalidomide, a sedative drug, may induce skeletal defects in the offspring of treated females when administered in the early stages of pregnancy. McColl, Globus and Robinson (1963) reported that certain skeletal defects could be produced in the offspring of Sprague-Dawley rats following chronic oral administration of thalidomide. Notable among the defects produced were malfomations of the sternum. [...]McGill UniversityGibson, M. (Supervisor)1965Electronic Thesis or Dissertationapplication/pdfenalephsysno: NNNNNNNNNTheses scanned by McGill Library.All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated.Master of Science. (Department of Zoology.) http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=117795
collection NDLTD
language en
format Others
sources NDLTD
topic Zoology.
Sternum.
Rodents -- Embryology.
Rats.
Thalidomide.
spellingShingle Zoology.
Sternum.
Rodents -- Embryology.
Rats.
Thalidomide.
Globus, Morton.
A histological and histochemical study of the development of the sternum in thalidomide-treated rats.
description It is now well established that certain chemical compounds, administered to animals in early pregnancy, can adversely influence the development of the fetus, resulting in congenital malformations. Recently, it bas been shown that thalidomide, a sedative drug, may induce skeletal defects in the offspring of treated females when administered in the early stages of pregnancy. McColl, Globus and Robinson (1963) reported that certain skeletal defects could be produced in the offspring of Sprague-Dawley rats following chronic oral administration of thalidomide. Notable among the defects produced were malfomations of the sternum. [...]
author2 Gibson, M. (Supervisor)
author_facet Gibson, M. (Supervisor)
Globus, Morton.
author Globus, Morton.
author_sort Globus, Morton.
title A histological and histochemical study of the development of the sternum in thalidomide-treated rats.
title_short A histological and histochemical study of the development of the sternum in thalidomide-treated rats.
title_full A histological and histochemical study of the development of the sternum in thalidomide-treated rats.
title_fullStr A histological and histochemical study of the development of the sternum in thalidomide-treated rats.
title_full_unstemmed A histological and histochemical study of the development of the sternum in thalidomide-treated rats.
title_sort histological and histochemical study of the development of the sternum in thalidomide-treated rats.
publisher McGill University
publishDate 1965
url http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=117795
work_keys_str_mv AT globusmorton ahistologicalandhistochemicalstudyofthedevelopmentofthesternuminthalidomidetreatedrats
AT globusmorton histologicalandhistochemicalstudyofthedevelopmentofthesternuminthalidomidetreatedrats
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