| Summary: | It is now well established that certain chemical compounds, administered to animals in early pregnancy, can adversely influence the development of the fetus, resulting in congenital malformations. Recently, it bas been shown that thalidomide, a sedative drug, may induce skeletal defects in the offspring of treated females when administered in the early stages of pregnancy. McColl, Globus and Robinson (1963) reported that certain skeletal defects could be produced in the offspring of Sprague-Dawley rats following chronic oral administration of thalidomide. Notable among the defects produced were malfomations of the sternum. [...]
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