The genetics basis of spontaneous cleft lip in the inbred a/jax mouse strain.

• Main Author: Davidson, Jefferson. G.
• Other Authors: Fraser, F. (Supervisor)
• Format: Others
• Language: en
• Published: McGill University 1964
• Subjects: Genetics.
• Online Access: http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=115405

Although genetic studies are devoted, for the most part, to characters showing clear cut segregation, a great many genetically determined defects show familial patterns which cannot be explained by a difference at a single genetic locus or even a very few loci. These defects are often biologically important and, in spite of the difficulties involved in their analysis, deserve more intensive study. The studies which have been done, such as those of Wright (1934a, 1934b), Reed (1936), Gruneberg (1952), Lerner (1954), and Landauer (1957), attempt to explain the apparently non-Mendelian behaviour of the trait in question by invoking either reduced penetrance or multigenic inheritance, or both.