In vitro transport of imino acids and glycine in rat kidney cortex.

• Main Author: Wilson, Onslow. H.
• Other Authors: Scriver, C. (Supervisor)
• Format: Others
• Language: en
• Published: McGill University 1963
• Subjects: Investigative Medicine.
• Online Access: http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=115319

In-vivo investigations of renal tubular transport of the imino acids and glycine in man and rat have revealed that these compounds may share a common membrane transfer mechanism. However, the locus of "commonness” cannot be resolved by such techniques. In-vitro studies reported in this communication permit the application of Michaelis-Menten formulation to the kinetics of transport of these compounds in rat kidney cortex slices. The data indicate that L-proline, hydroxy-L-proline and glycine cannot be transported by identical mechanisms but that there is some aspect of these systems which is common. The order of affinity for transport in-vitro is proline > hydroxyproline > glycine, confirming in-vivo observations. The relation of these findings to the control of imino acid and glycine transport under certain genetic and maturational conditions in man, is discussed. A proposal as to the locus of commonness in transport generally, and more specifically in the transport of glycine and the imino acids, is discussed.