Alternate pathways of tryptophan metabolism in the rat.

• Main Author: Townsend, Edith. E.
• Other Authors: Sourkes, T. (Supervisor)
• Format: Others
• Language: en
• Published: McGill University 1959
• Subjects: Biochemistry.
• Online Access: http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=112099

The work to be presented in this thesis concerns the divergent pathways of tryptophan metabolism to the 5-hydroxyindoles and to kynurenine. More specifically an attempt has been made to elucidate the role of dietary tryptophan in the operation of these two pathways. Previous investigators have implied that thiamine is involved in the kynurenine-forming pathway. Both nutritional studies and experiments in vitro were carried out to determine just where thiamine (or thiamine pyrophosphate, its coenzyme form) exerts its action.