| Summary: | Studies concerned, in whole or in part, with the manifold aspects of histamine release began with the first, albeit unrecognized, report of the phenomenon by Schmidt-Mulheim (1880), in which "peptone-shock" in the dog was described. No attempt is made, herein, to provide a comprehensive survey of the literature that has since accumulated. The review of the earlier literature is restricted to those papers which have been most helpful to the author in gaining an understanding of previously established facts; in this, invaluable assistance has been provided by the existing reviews, especially those of Feldberg (1941), Dragstedt (1941), Dale (1950) and Code (1952). [...]
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