Empirical Testing of the Evolutionary Theories of Aging Using Laboratory-Evolved Yeast Mutants with Extended Lifespan
We recently conducted a multistep selection of long-lived yeast mutants by a lasting exposure to lithocholic acid, a longevity-extending natural compound. Three selected long-lived mutant strains, called 3, 5 and 12, were able to maintain their extended lifespans following numerous passages in mediu...