Synthesis of aromatic peptide nucleic acids

Synthesis of aromatic peptide nucleic acids

The synthesis of two analogues of Aromatic Peptide Nucleic Acids (APNAs) monomers was successfully achieved. These Peptide Nucleic Acid analogues could be used as building blocks for the synthesis of oligomers with the DNA and RNA recognition properties of PNAs in addition to a more hydrophobic back...

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Main Author: Boyd, Michael J
Format: Others
Published: 1999
Online Access:http://spectrum.library.concordia.ca/856/1/MQ43635.pdf
Boyd, Michael J <http://spectrum.library.concordia.ca/view/creators/Boyd=3AMichael_J=3A=3A.html> (1999) Synthesis of aromatic peptide nucleic acids. Masters thesis, Concordia University.
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spelling ndltd-LACETR-oai-collectionscanada.gc.ca-QMG.8562013-10-22T03:41:03Z Synthesis of aromatic peptide nucleic acids Boyd, Michael J The synthesis of two analogues of Aromatic Peptide Nucleic Acids (APNAs) monomers was successfully achieved. These Peptide Nucleic Acid analogues could be used as building blocks for the synthesis of oligomers with the DNA and RNA recognition properties of PNAs in addition to a more hydrophobic backbone which may improve cell permeability. Such analogues may be useful as antisense/antigene therapeutic agents. A first generation APNA hexamer, composed of monomers of general structure A was synthesized in solution. Thermal denaturation studies failed to indicate if these compounds hybridize to DNA or RNA. The second generation APNA monomers ( B ) were incorporated into PNA hexamers by solid phase peptide synthesis. The resulting PNA/APNA chimeras hybridize to both DNA and RNA by triple helix formation, however these complexes were found to be less stable than the unmodified PNAs 1999 Thesis NonPeerReviewed application/pdf http://spectrum.library.concordia.ca/856/1/MQ43635.pdf Boyd, Michael J <http://spectrum.library.concordia.ca/view/creators/Boyd=3AMichael_J=3A=3A.html> (1999) Synthesis of aromatic peptide nucleic acids. Masters thesis, Concordia University. http://spectrum.library.concordia.ca/856/
collection NDLTD
format Others
sources NDLTD
description The synthesis of two analogues of Aromatic Peptide Nucleic Acids (APNAs) monomers was successfully achieved. These Peptide Nucleic Acid analogues could be used as building blocks for the synthesis of oligomers with the DNA and RNA recognition properties of PNAs in addition to a more hydrophobic backbone which may improve cell permeability. Such analogues may be useful as antisense/antigene therapeutic agents. A first generation APNA hexamer, composed of monomers of general structure A was synthesized in solution. Thermal denaturation studies failed to indicate if these compounds hybridize to DNA or RNA. The second generation APNA monomers ( B ) were incorporated into PNA hexamers by solid phase peptide synthesis. The resulting PNA/APNA chimeras hybridize to both DNA and RNA by triple helix formation, however these complexes were found to be less stable than the unmodified PNAs
author Boyd, Michael J
spellingShingle Boyd, Michael J
Synthesis of aromatic peptide nucleic acids
author_facet Boyd, Michael J
author_sort Boyd, Michael J
title Synthesis of aromatic peptide nucleic acids
title_short Synthesis of aromatic peptide nucleic acids
title_full Synthesis of aromatic peptide nucleic acids
title_fullStr Synthesis of aromatic peptide nucleic acids
title_full_unstemmed Synthesis of aromatic peptide nucleic acids
title_sort synthesis of aromatic peptide nucleic acids
publishDate 1999
url http://spectrum.library.concordia.ca/856/1/MQ43635.pdf
Boyd, Michael J <http://spectrum.library.concordia.ca/view/creators/Boyd=3AMichael_J=3A=3A.html> (1999) Synthesis of aromatic peptide nucleic acids. Masters thesis, Concordia University.
work_keys_str_mv AT boydmichaelj synthesisofaromaticpeptidenucleicacids
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