The effect of HIV protease inhibitors on insulin binding, triglyceride synthesis, lipolysis, and insulin signaling in 3T3-L1 adipocytes
Retroviral protease inhibitors used as therapy for HIV-infection have been causally associated with serious metabolic side effects, including peripheral lipodystrophy, central adiposity, hyperlipidaemia, insulin resistance, and in some cases, type 2 diabetes. The etiology of this characteristic clin...