Design, Synthesis and Biological Evaluation of 2,4-Disubstituted Pyrimidine Derivatives: Multifunctional Candidates as Potential Treatment Options for Alzheimer’s Disease

Design, Synthesis and Biological Evaluation of 2,4-Disubstituted Pyrimidine Derivatives: Multifunctional Candidates as Potential Treatment Options for Alzheimer’s Disease

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Alzheimer’s disease (AD) is a highly complex and rapidly progressive neurodegenerative disorder characterized by the systemic collapse of cognitive function and formation of dense amyloid-β (Aβ) plaques and neurofibrillary tangles (NFTs). AD pathology is derived from the cholinergic, amyloid and tau...

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Bibliographic Details
Main Author:	Mohamed, Tarek
Language:	en
Published:	2011
Subjects:	Alzheimer's disease Medicinal Chemistry Cholinesterase Amyloid Pyrimidine BACE-1 Pharmacy
Online Access:	http://hdl.handle.net/10012/6183

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