Synthetic, Mechanistic and Theoretical Studies Related to the Kinamycin Antibiotics
The synthesis of an isosteric-isoelectronic analogue of prekinamycin, an N-cyanobenzo[b]carbazoloquinone 2.1, is described. The key steps include a Vilsmeier-Haack formylation, a regioselective bromination, a Buchwald-Hartwig cross-coupling, a palladium mediated oxidative cyclization and N-cyanation...
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| Language: | en |
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2011
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| Online Access: | http://hdl.handle.net/10012/5929 |
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