Effect of Early Life Vitamin D Supplementation on Bone Development

• Main Author: Fielding, Kristina Anne
• Other Authors: Ward, Wendy
• Language: en_ca
• Published: 2012
• Subjects: intervention study; early programming; vitamin D; bone development; inflammatory bowel disease; CD-1 mice; IL-10 KO mice; 0570
• Online Access: http://hdl.handle.net/1807/42906

Vitamin D is important for bone development with immunomodulatory effects. This study investigated whether feeding CD-1 and interleukin 10 (IL-10) knockout (KO) dams low (25 IU/kg diet) or high (5,000 IU/kg diet) vitamin D affected bone health of dams as well as their offspring. Offspring were weaned to 1 of the 2 diets and followed to young adulthood. Unlike CD-1 dams, IL-10 KO dams experienced greater femur strength with high vitamin D. CD-1 male offspring had reduced femur neck strength and female offspring had smaller, weaker femurs, and weaker lumbar vertebra 2 (LV2) with high maternal vitamin D. IL-10 KO male offspring had larger femurs and female offspring had stronger femurs when weaned to high vitamin D. Low vitamin D did not adversely impact bone health but the optimal level of dietary vitamin D seems to differ between healthy and inflammatory states.