Role of Hexokinase 2 (HK2) in Modulating Tumor Metabolism and Response to Therapy in Glioblastoma
Glioblastoma (GBM), similar to many other cancers, exhibits enhanced aerobic glycolysis with concomitant lactate production, a phenomenon known as the Warburg effect. We have demonstrated that preferential expression of Hexokinase 2 (HK2) is a critical mediator of metabolic reprograming in GBMs and...
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| Language: | en_ca |
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2013
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| Online Access: | http://hdl.handle.net/1807/42661 |