Sequence-selective DNA Binding by Basic Region/Leucine Zipper Proteins at Noncognate Gene Regulatory Sequences
This thesis explores how basic region/leucine zipper (bZIP) transcription factors target gene regulatory sequences. The GCN4 bZIP binds to more than one target site [CRE (TGACGTCA) and cognate AP-1 (TGACTCA)] and exhibits flexibility in -helical structure. These observations suggest that the GCN4 b...
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| Language: | en_ca |
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2012
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| Online Access: | http://hdl.handle.net/1807/32676 |