Role of Molecular Chaperones in the Biosynthesis of Anion Exchanger 1
Mutations in the SLC4A1 gene result in misfolding and trafficking defects of the human erythroid (AE1) and kidney (kAE1) forms of the anion exchanger 1 glycoprotein. This affects the amount of functional protein at the cell surface, resulting in hematological and renal diseases. In this thesis, the...
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| Language: | en_ca |
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2011
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| Online Access: | http://hdl.handle.net/1807/29838 |