Structural Studies of the Inhibitory Role of Tctex-1 for the Microtubule-associated RhoGEF Lfc
Lfc is a guanine nucleotide exchange factor (GEF) for RhoA and is negatively regulated by its association with the microtubule array. Tctex-1, a light chain subunit of the dynein motor complex, was identified as an Lfc-interacting protein in a yeast two-hybrid screen. In mouse embryonic fibroblast (...
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| Language: | en_ca |
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2011
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| Online Access: | http://hdl.handle.net/1807/29572 |