The Role of the Di-arginine "R553AR555" Motif in Modulating Trafficking and Function of the Major Cystic Fibrosis Causing Mutant (DeltaF508-CFTR)
Cystic Fibrosis (CF) is an autosomal recessive disease that arises from mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene. The deletion of phenylalanine-508 (ΔF508-CFTR) is the most prevalent CF mutation and results in a misfolded protein that fails to exit the endopl...
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| Language: | en_ca |
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2010
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| Online Access: | http://hdl.handle.net/1807/26280 |