Epigenetic Basis for Heterogeneity in VCAM-1 Gene Expression Patterns in Cytokine Activated Vascular Endothelium
Vascular cell adhesion molecule-1 (VCAM-1) is a cytokine-activated protein present on endothelial cells (ECs). Our laboratory has provided evidence that DNA methylation, a mark associated with gene silencing, is fundamental for regulating VCAM-1 expression. First, we showed that RNA polymerase II,...
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| Language: | en_ca |
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2010
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| Online Access: | http://hdl.handle.net/1807/25633 |