REM Sleep-active Pedunculopontine Tegmental Neurons Supresses REM Sleep Expression and Respiratory Network Activity
The mechanisms underlying the generation of rapid eye movement (REM) sleep are poorly understood. Despite a lack of direct support, neurons maximally active during REM sleep (REM sleep-active) located in the pedunculopontine tegmental nucleus (PPTn) are hypothesized to generate this state and its co...
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ndltd-LACETR-oai-collectionscanada.gc.ca-OTU.1807-256032013-04-20T05:21:42ZREM Sleep-active Pedunculopontine Tegmental Neurons Supresses REM Sleep Expression and Respiratory Network ActivityGrace, KevinREM sleepPedunculopontine Tegmental NucleusBreathing5HT1A Receptor03170719The mechanisms underlying the generation of rapid eye movement (REM) sleep are poorly understood. Despite a lack of direct support, neurons maximally active during REM sleep (REM sleep-active) located in the pedunculopontine tegmental nucleus (PPTn) are hypothesized to generate this state and its component phenomenology. This hypothesis has never been directly tested, since the results of selectively inhibiting this cell-group have never been determined. Using microdialysis, electrophysiology, histochemical and pharmacological methods in freely-behaving rats (n=22) instrumented for sleep-wake state and respiratory muscle recordings, I selectively inhibited REM sleep-active PPTn neurons. Contrary to the prevailing hypothesis, I showed that REM sleep-active PPTn neurons suppress REM sleep by limiting the frequency of its onset. These neurons also shape the impact of REM sleep on breathing. REM sleep-active PPTn neurons restrain behavioural activation of upper-airway musculature during REM sleep, while depressing breathing rate and respiratory activation of the upper-airway musculature across sleep-wake-states.Horner, Richard2010-112010-12-31T21:27:04ZNO_RESTRICTION2010-12-31T21:27:04Z2010-12-31T21:27:04ZThesishttp://hdl.handle.net/1807/25603en_ca |
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REM sleep Pedunculopontine Tegmental Nucleus Breathing 5HT1A Receptor 0317 0719 |
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REM sleep Pedunculopontine Tegmental Nucleus Breathing 5HT1A Receptor 0317 0719 Grace, Kevin REM Sleep-active Pedunculopontine Tegmental Neurons Supresses REM Sleep Expression and Respiratory Network Activity |
description |
The mechanisms underlying the generation of rapid eye movement (REM) sleep are poorly understood. Despite a lack of direct support, neurons maximally active during REM sleep (REM sleep-active) located in the pedunculopontine tegmental nucleus (PPTn) are hypothesized to generate this state and its component phenomenology. This hypothesis has never been directly tested, since the results of selectively inhibiting this cell-group have never been determined. Using microdialysis, electrophysiology, histochemical and pharmacological methods in freely-behaving rats (n=22) instrumented for sleep-wake state and respiratory muscle recordings, I selectively inhibited REM sleep-active PPTn neurons. Contrary to the prevailing hypothesis, I showed that REM sleep-active PPTn neurons suppress REM sleep by limiting the frequency of its onset. These neurons also shape the impact of REM sleep on breathing. REM sleep-active PPTn neurons restrain behavioural activation of upper-airway musculature during REM sleep, while depressing breathing rate and respiratory activation of the upper-airway musculature across sleep-wake-states. |
author2 |
Horner, Richard |
author_facet |
Horner, Richard Grace, Kevin |
author |
Grace, Kevin |
author_sort |
Grace, Kevin |
title |
REM Sleep-active Pedunculopontine Tegmental Neurons Supresses REM Sleep Expression and Respiratory Network Activity |
title_short |
REM Sleep-active Pedunculopontine Tegmental Neurons Supresses REM Sleep Expression and Respiratory Network Activity |
title_full |
REM Sleep-active Pedunculopontine Tegmental Neurons Supresses REM Sleep Expression and Respiratory Network Activity |
title_fullStr |
REM Sleep-active Pedunculopontine Tegmental Neurons Supresses REM Sleep Expression and Respiratory Network Activity |
title_full_unstemmed |
REM Sleep-active Pedunculopontine Tegmental Neurons Supresses REM Sleep Expression and Respiratory Network Activity |
title_sort |
rem sleep-active pedunculopontine tegmental neurons supresses rem sleep expression and respiratory network activity |
publishDate |
2010 |
url |
http://hdl.handle.net/1807/25603 |
work_keys_str_mv |
AT gracekevin remsleepactivepedunculopontinetegmentalneuronssupressesremsleepexpressionandrespiratorynetworkactivity |
_version_ |
1716583457626259456 |