Enhancing Production of Recombinant BMP-2 in Mammalian Cell Culture Systems by Inhibition of Pro-protein Cleavage using 9DR Peptides
Introduction: Mammalian cell recombinant bone morphogenetic protein (rBMP) synthesis is reported to be poor. The BMP pro-domain may be involved in folding, stability and secretion. Objectives: Investigate the effect of inhibition of pro-domain cleavage on rhBMP-2 production. Methods: CHO cells tra...
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| Format: | Others |
| Language: | en_ca |
| Published: |
2008
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| Online Access: | http://hdl.handle.net/1807/11175 |