The Effects of Acute Running Induced Neuronal Activation on Cerebral GLUT1 and Vascular Plasticity

• Main Author: Liang, Jacky
• Language: en
• Published: 2011
• Subjects: neuronal plasticity; glucose transporter; GLUT1; CD31; exercise; immunohistochemistry; Western blot; cluster of differentiation 31; Platelet endothelial cell adhesion molecule
• Online Access: http://hdl.handle.net/10393/20396

Morphologic and metabolic change is a known property of the adult brain. A number of behavioural tasks alter local cerebral blood flow and glucose utilisation. The expression of the glucose transporter 1 (GLUT1), which allows the entry of glucose to the brain, also has been shown to change in response to long-lasting neuronal activation. However, little is known about the effect of acute neuronal activation on GLUT1 expression. Using immunohistochemistry and Western blot, we investigated cerebral GLUT1 expression and vasculature density in mice undergoing a 48-hour voluntary wheel running period. The results showed that the striatum was the main region where GLUT1 protein was up-regulated: There was a trend for GLUT1 expression and blood vessels density to be associated with the distance run during the experiment. These results indicate that short-term increased neuronal activation is associated with rapid changes in glucose transport and possibly vascular remodelling.