The Combination of Carboxylesterase-Expressing Oncolytic Vaccinia Virus and Irinotecan

The Combination of Carboxylesterase-Expressing Oncolytic Vaccinia Virus and Irinotecan

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This project combines oncolytic Vaccinia virus (VV) with irinotecan (CPT-11) for the treatment of cancer. VV can infect, replicate in and destroy cancer cells, yet leave healthy cells relatively unaffected. CPT-11 is a chemotherapeutic of which ~5% is converted to the more active chemotherapeutic SN...

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Bibliographic Details
Main Author: Becker, Michelle Caitlin
Language:en
Published: 2013
Subjects:
Cancer
Oncolytic virus
Vaccinia virus
Carboxylesterase
Irinotecan
CPT-11
Gene-directed enzyme prodrug therapy
Vascular endothelial growth factor
Angiogenesis
Virus delivery
Virus spread
Plaque purification
Virus aggregation
Virus filtration
Online Access:http://hdl.handle.net/10393/23653

Internet

http://hdl.handle.net/10393/23653

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