Structural and functional characterization of E2A:KIX interactions in leukemia

Structural and functional characterization of E2A:KIX interactions in leukemia

The E2A proteins are transcription factors critical for B-lymphopoiesis. A chromosomal translocation involving the E2A gene promotes acute lymphoblastic leukemia (ALL) through expression of the oncoprotein E2A-PBX1. Two activation domains of E2A-PBX1, AD1 and AD2, have been implicated in transcripti...

Full description

Bibliographic Details
Main Author: Denis, Christopher
Other Authors: Queen's University (Kingston, Ont.). Theses (Queen's University (Kingston, Ont.))
Language:en
en
Published: 2012
Subjects:
leukemia
protein-protein interactions
NMR spectroscopy
structural biology
Online Access:http://hdl.handle.net/1974/7469

Similar Items

Similar Items