Characterizing drug interactions in the substrate binding pocket of the P-glycoprotein multidrug efflux pump
P-glycoprotein (Pgp, ABCB1) is a polyspecific efflux transporter implicated in multidrug resistance in human cancers. In this study, tetramethylrhodamine-5-carbonyl azide (AzTMR) was covalently crosslinked to the Pgp drug binding pocket with a stoichiometry of 1. The Pgp-AzTMR adduct was functionall...
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| Language: | en |
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2012
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| Online Access: | http://hdl.handle.net/10214/3309 |