THE DESIGN AND SYNTHESIS OF PHOSPHONATE-BASED INHIBITORS OF NUCLEOTIDYLYLTRANSFERASES
Nucleotidylyltransferase inhibitors are designed to target enzymes responsible for one step of cell wall biosynthesis in Gram-positive, Gram-negative and mycobacteria. Glucose 1-phosphate thymidylyltransferase Cps2L/RmlA (EC 2.7.7.24) is an enzyme essential for the growth and proliferation of many b...
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| Language: | en |
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2013
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| Online Access: | http://hdl.handle.net/10222/31395 |