Identification and genetic mapping of perR, a novel stationary phase gene that mediates oxidative stress protection in Escherichia coli

Identification and genetic mapping of perR, a novel stationary phase gene that mediates oxidative stress protection in Escherichia coli

Show other versions (2)

In bacteria, stationary phase is a time of intricate cellular metabolic and physiological changes necessary for the maintenance of essential cell functions and resistance to environmental stresses, such as oxidative stress. This study investigated 'perR'; a locus potentially involved in t...

Full description

Bibliographic Details
Main Author: Strutinsky, Jeanna Brandy Lee
Format: Others
Language:en
en_US
Published: 2007
Online Access:http://hdl.handle.net/1993/2339
id ndltd-LACETR-oai-collectionscanada.gc.ca-MWU.anitoba.ca-dspace#1993-2339
record_format oai_dc
spelling ndltd-LACETR-oai-collectionscanada.gc.ca-MWU.anitoba.ca-dspace#1993-23392013-01-11T13:30:06ZStrutinsky, Jeanna Brandy Lee2007-06-01T19:21:38Z2007-06-01T19:21:38Z2000-09-01T00:00:00Zhttp://hdl.handle.net/1993/2339In bacteria, stationary phase is a time of intricate cellular metabolic and physiological changes necessary for the maintenance of essential cell functions and resistance to environmental stresses, such as oxidative stress. This study investigated 'perR'; a locus potentially involved in the hydrogen peroxide resistance of 'Escherichia coli' in stationary phase. The strain UM397 containing a mutation in 'perR' was created as part of this study and showed 13.6 fold greater sensitivity to H2O2 in stationary phase when compared to its parent strain MG1655. This suggested that PerR is involved in oxidative stress resistance in stationary phase. Further, the predicted sequence of PerR is similar to LysR-type transcriptional regulators, suggesting a regulatory role for the protein.5140582 bytes184 bytesapplication/pdftext/plainenen_USIdentification and genetic mapping of perR, a novel stationary phase gene that mediates oxidative stress protection in Escherichia coliMicrobiologyM.Sc.
collection NDLTD
language en
en_US
format Others
sources NDLTD
description In bacteria, stationary phase is a time of intricate cellular metabolic and physiological changes necessary for the maintenance of essential cell functions and resistance to environmental stresses, such as oxidative stress. This study investigated 'perR'; a locus potentially involved in the hydrogen peroxide resistance of 'Escherichia coli' in stationary phase. The strain UM397 containing a mutation in 'perR' was created as part of this study and showed 13.6 fold greater sensitivity to H2O2 in stationary phase when compared to its parent strain MG1655. This suggested that PerR is involved in oxidative stress resistance in stationary phase. Further, the predicted sequence of PerR is similar to LysR-type transcriptional regulators, suggesting a regulatory role for the protein.
author Strutinsky, Jeanna Brandy Lee
spellingShingle Strutinsky, Jeanna Brandy Lee
Identification and genetic mapping of perR, a novel stationary phase gene that mediates oxidative stress protection in Escherichia coli
author_facet Strutinsky, Jeanna Brandy Lee
author_sort Strutinsky, Jeanna Brandy Lee
title Identification and genetic mapping of perR, a novel stationary phase gene that mediates oxidative stress protection in Escherichia coli
title_short Identification and genetic mapping of perR, a novel stationary phase gene that mediates oxidative stress protection in Escherichia coli
title_full Identification and genetic mapping of perR, a novel stationary phase gene that mediates oxidative stress protection in Escherichia coli
title_fullStr Identification and genetic mapping of perR, a novel stationary phase gene that mediates oxidative stress protection in Escherichia coli
title_full_unstemmed Identification and genetic mapping of perR, a novel stationary phase gene that mediates oxidative stress protection in Escherichia coli
title_sort identification and genetic mapping of perr, a novel stationary phase gene that mediates oxidative stress protection in escherichia coli
publishDate 2007
url http://hdl.handle.net/1993/2339
work_keys_str_mv AT strutinskyjeannabrandylee identificationandgeneticmappingofperranovelstationaryphasegenethatmediatesoxidativestressprotectioninescherichiacoli
_version_ 1716574920039727104

Similar Items