Mutational analysis of the dsRNA binding domain of Vaccinia Virus E3 protein
Vaccinia virus E3 protein is known to bind double-stranded RNA and mediate interferon resistance. Alanine scanning mutagenesis was performed on its dsRNA binding domain, sufficient for wild-type tropism and immune suppression in vitro, and dsRNA binding and host range function assayed. Residues in...
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2011
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| Online Access: | http://hdl.handle.net/1993/4852 |