Production and characterization of YAC transgenic mice expressing the normal and mutant Huntington’s disease gene
Insights into how polyglutamine (Q) expansion in the Huntington's disease (HD) protein, huntingtin (htt), results in neurotoxicity in vivo can be achieved with the development of an animal model. No such model exists for HD with accurate spatial and temporal expression of a full-length mutan...
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| Language: | English |
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2009
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| Online Access: | http://hdl.handle.net/2429/9881 |