Characterizing Tumour Vessels using MRI and Histology - A novel dual injection MR protocol to study tumour blood vessel permeability
Galbumin, an MR contrast agent is characterized for use in a new class of animal MR experiments. It’s suitability as both a T1 and T2 agent was assessed and it was found that although Galbumin’s relaxivity (4.33 to 5.77 (mM · sec)−1 was comparable to Gd-DTPA, the solution was not available at a h...
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| Language: | English |
| Published: |
2009
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| Online Access: | http://hdl.handle.net/2429/7804 |
| Summary: | Galbumin, an MR contrast agent is characterized for use in a new class of animal MR experiments.
It’s suitability as both a T1 and T2 agent was assessed and it was found that although
Galbumin’s relaxivity (4.33 to 5.77 (mM · sec)−1 was comparable to Gd-DTPA, the solution was
not available at a high enough concentration to achieve similar T1 weighted effects. Further, it
was deemed an unworthy candidate for T2 -weighted imaging as it’s magnetic susceptibility was
much too low (2.95 ppm/mM). Finally, we established a theoretical basis for a novel dual contrast
agent MR protocol to investigate blood vessel permeability, extracted from previously published
work [1] on modelling MR contrast agents. The over-arching goal of this study is to use the live
imaging capabilities of MR combined with traditional immunohistochemical techniques to more
accurately characterize tumour vessel permeability. |
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