Reactivation of TK-deficient Herpes simplex virus and homopolymer mutational hot spots
The majority of herpes simplex virus (HSV) isolates resistant to acyclovir (ACV) have a deficiency of thymidine kinase (TD[sup D]). Such mutants are able to establish latency in animal models but are unable to reactivate which has contributed to the clinical dogma that, following effective eradicat...
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| Language: | English |
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2009
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| Online Access: | http://hdl.handle.net/2429/6796 |